Record Information
public_id FDB000511
Chemical Information
name L-Carnosine
description Occurs in meats Carnosine (beta-alanyl-L-histidine) is a dipeptide of the amino acids beta-alanine and histidine. It is highly concentrated in muscle and brain tissues.; Carnosine (beta-alanyl-L-histidine) is found exclusively in animal tissues. It is a dipeptide of the amino acids beta-alanine and histidine. Carnosine has the potential to suppress many of the biochemical changes (e.g., protein oxidation, glycation, AGE formation, and cross-linking) that accompany aging and associated pathologies (PMID 16804013). It is highly concentrated in muscle and brain tissues. Some autistics patients take it as a dietary supplement, and attribute an improvement in their condition to it. Supplemental carnosine may increase corticosterone levels. This may explain the "hyperactivity" seen in autistic subjects at higher doses. Carnosine also exhibits some antioxidant effects. The antioxidant mechanism of carnosine is attributed to its chelating effect against metal ions, superoxide dismutase (SOD)-like activity, ROS and free radicals scavenging ability (PMID 16406688); Some studies have detected beneficial effects of N-acetyl-carnosine in preventing and treating cataracts of the eyes; in one of these, carnosine was found to reduce cloudiness in rat lenses that were exposed to guanidine to cause cataracts. However, claims that carnosine confers these and other posited ophthamological benefits are, as of yet, insufficiently supported for endorsement by the mainstream medical community; Britain's Royal College of Ophthamologists, for instance, has asserted that neither safety nor efficacy has been sufficiently demonstrated to recommend carnosine's use as a topical treatment for cataracts.
cas_number 305-84-0
Properties
created_at 2010-04-08 22:04:36
updated_at 2011-10-30 14:09:58
moldb_smiles NCCC(=O)NC(CC1=CNC=N1)C(O)=O
moldb_formula C9H14N4O3
moldb_average_mass 226.2325
moldb_inchi InChI=1S/C9H14N4O3/c10-2-1-8(14)13-7(9(15)16)3-6-4-11-5-12-6/h4-5,7H,1-3,10H2,(H,11,12)(H,13,14)(H,15,16)
moldb_mono_mass 226.106590334
moldb_inchikey InChIKey=CQOVPNPJLQNMDC-UHFFFAOYSA-N
moldb_iupac 2-(3-aminopropanamido)-3-(1H-imidazol-4-yl)propanoic acid
Structure Thumb
Synonyms
Synonym Source
β-alanyl-l-histidine biospider
Beta-alanyl-l-histidine biospider
L-carnosine biospider
L-histidine, n-β-alanyl- biospider
Carnosine; L-form db_source