Record Information
public_id FDB012703
Chemical Information
name D-Galactose
description The free sugar has been detected in some fruits. Polysaccharides agar, gum arabic, mesquite gum, western larch gum and many plant mucilages and gums contain galactose D-Galactose is an aldohexose that occurs naturally in the D-form in lactose, cerebrosides, gangliosides, and mucoproteins. D-Galactose is an energy-providing nutrient and also a necessary basic substrate for the biosynthesis of many macromolecules in the body. Metabolic pathways for D-Galactose are important not only for the provision of these pathways but also for the prevention of D-Galactose and D-Galactose metabolite accumulation. The main source of D-Galactose is lactose in the milk of mammals, but it can also be found in some fruits and vegetables. Utilization of D-Galactose in all living cells is initiated by the phosphorylation of the hexose by the enzyme galactokinase (E.C. 2.7.1.6) (GALK) to form D-Galactose-1-phosphate. In the presence of D-Galactose-1-phosphate uridyltransferase (E.C. 2.7.7.12) (GALT) D-Galactose-1-phosphate is exchanged with glucose-1-phosphate in UDP-glucose to form UDP-galactose. Glucose-1-phosphate will then enter the glycolytic pathway for energy production. Deficiency of the enzyme GALT in galactosemic patients leads to the accumulation of D-Galactose-1-phosphate. Classic galactosemia-a term that denotes the presence of D-Galactose in the blood is the rare inborn error of D-Galactose metabolism, diagnosed by the deficiency of the second enzyme of the D-Galactose assimilation pathway, GALT, which, in turn, is caused by mutations at the GALT gene. (PMID: 15256214, 11020650, 10408771); In organic chemistry, a hexose is a monosaccharide with six carbon atoms, having the chemical formula C6H12O6. Hexoses are classified by functional group, with aldohexoses having an aldehyde at position 1, and ketohexoses having a ketone at position 2.
cas_number 59-23-4
Properties
created_at 2010-04-08 22:10:19
updated_at 2011-10-30 14:25:00
moldb_smiles OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@H]1O
moldb_formula C6H12O6
moldb_average_mass 180.1559
moldb_inchi InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3+,4+,5-,6?/m1/s1
moldb_mono_mass 180.063388116
moldb_inchikey InChIKey=WQZGKKKJIJFFOK-SVZMEOIVSA-N
moldb_iupac (3R,4S,5R,6R)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol
Structure Thumb
Synonyms
Synonym Source
(+)-galactose biospider
D-(+)-galactose biospider
D-galactose biospider
Galactose biospider
Galactose, d- biospider
D-galactopyranose manual