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Name Description
id 49
T3DB ID T3D0053
Name Nickel
Class SmallMolecule
Description Nickel is a solid, silver-white, hard, malleable transition metal with an atomic number of 28. It resists corrosion even at high temperatures. It is present in many alloys in widespread use, including stainless steels. It may also be present as an impurity in any alloy. Nickel is used in the production of coins, jewellery, and nickel-cadmium batteries, and as a catalyst for the hydrogenation of liquid oils to solid fats such as oleomargarine and vegetable shortening. Nickel-containing dental alloys continue to be used successfully in the provision of various forms of dental care. Many of these alloys have applications in the construction of restorations designed to remain in clinical service for many years, including crowns, fixed bridgework, and removable partial dentures. Furthermore, nickel containing alloys find extensive application in orthodontics, including metallic brackets, arch wires, bands, springs and ligature wires. Many instruments and devises, for example, endodontic instruments also contain nickel. Allergic responses are mediated through the immune system. In a sensitized individual, allergic responses can be initiated by relatively small amounts of the allergen; for example, if nickel ions are released from a nickel plated material following direct and prolonged contact with the skin. Individuals are first sensitized to the allergen. Subsequent exposures, if sufficiently high, may then result in an allergic reaction. A number of allergens are used in the clinical practice of dentistry, notably eugenol, mercury, nickel, chromium, cobalt, components of resin-based materials and a host of other chemical agents. The majority of dental allergies, including allergic responses to nickel-containing dental alloys, comprise Type IV hypersensitivity reactions, cell-mediated by T-lymphocytes. Physiologically, it exists as an ion in the body.(A7688, A7689).
Categories "Household Toxin", "Industrial/Workplace Toxin", "Pollutant", "Airborne Pollutant", "Food Toxin", "Natural Toxin"
Types "Inorganic Compound", "Metal", "Nickel Compound", "Pollutant", "Food Toxin", "Metabolite", "Household Toxin", "Industrial/Workplace Toxin", "Natural Compound"
Synonyms "Metallic Nickel", "Ni(2+)", "Ni2+", "Nickel ion", "Nickel(2+)", "Nickel(2+) ion", "Nickel(II)", "Nickel(II) cation", "Nickel(II) ion"
CAS Number 7440-02-0
Chemical Formula Ni
Average Molecular Mass 58.69
Monoisotopic Mass 57.93
IUPAC Name nickel(2+) ion
Traditional Name nickel(2+) ion
SMILES [Ni++]
InChI Identifier InChI=1S/Ni/q+2
InChI Key InChIKey=VEQPNABPJHWNSG-UHFFFAOYSA-N
Kingdom Inorganic Compounds
Super Class Homogeneous Metal Compounds
Class Homogeneous Transition Metal Compounds
Sub Class
Direct Parent Homogeneous Transition Metal Compounds
Alternate Parents "Inorganic Cations"
Geometric Description Acyclic Compounds
Substituents "Inorganic Cation", "Acyclic Compound", "Homogeneous Transition Metal"
Descriptors "monoatomic dication (ChEBI)", "divalent metal cation (ChEBI)", "a cation (MetaCyc)", "nickel cation (ChEBI)"
Status Detected and Quantified
Origin Exogenous
Cellular Locations "Cytoplasm", "Extracellular"
Biofluids "Blood", "Cerebrospinal Fluid (CSF)", "Saliva", "Urine"
Tissues
Pathways
State Solid
Appearance Silvery-white metallic solid.
Melting Point 1455°C
Boiling Point
Solubility
LogP
Route of Exposure Oral (L41) ; inhalation (L41) ; dermal (L41)
Mechanism of Toxicity Nickel is known to substitute for other essential elements in certain enzmes, such as calcineurin. It is genotoxic, and some nickel compounds have been shown to promote cell proliferation. Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. Nickel has also been shown to alter several transcription factors, including hypoxia-inducible transcription factor, activating transcription factor, and NF-KB transcription factor. There is also evidence that nickel ions inhibit DNA repair, either by directly inhibiting DNA repair enzymes or competing with zinc ions for binding to zinc-finger DNA binding proteins, resulting in structural changes in DNA that prevent repair enzymes from binding. Nickel ions can also complex with a number of cellular ligands including amino acids, peptides, and proteins resulting in the generation of oxygen radicals, which induce base damage, DNA strand breaks, and DNA protein crosslinks. (L41, A40)
Metabolism Nickel is absorbed mainly through the lungs and gastrointestinal tract. Once in the body it enters the bloodstream, where it binds to albumin, L-histidine, and ?2-macroglobulin. Nickel tends to accumulate in the lungs, thyroid, kidney, heart, and liver. Absorbed nickel is excreted in the urine, whereas unabsorbed nickel is excreted in the faeces. (L41)
Toxicity LD50: 250 mg/kg (Intraperitoneal, Rat) (T26)
Lethal Dose
Carcinogenicity Metallic nickel is possibly carcinogenic to humons (Group 2B). Nickel compounds are carcinogenic to humans (Group 1). (L135)
Uses/Sources Pure nickel is mainly used to make alloys, which are found in items such as coins, jewelry, valves and heat exchangers. Nickel compounds are used for nickel plating, to color ceramics, to make some batteries, and as catalysts. (L41)
Minimum Risk Level Intermediate Inhalation: 0.0002 mg/m3 (L134) Chronic Inhalation: 0.00009 mg/m3 (L134)
Health Effects The most common harmful health effect of nickel in humans is an allergic reaction. This usually manifests as a skin rash, although some people experience asthma attacks. Long term inhahation of nickel causes chronic bronchitis and reduced lung function, as well as damage to the naval cavity. Ingestion of excess nickel results in damage to the stomach, blood, liver, kidneys, and immune system, as well as having adverse effects on reproduction and development. (L41)
Symptoms Symptoms of nickel poisoning include headache, nausea, vomiting, dizziness, irritability, and difficulty sleeping, followed by chest pains, sweating, rapid heart beat, and a dry cough. (L42)
Treatment Excess exposure to nickel is usually handled by preventing further exposure and symptomatic treatment. Nickel poisoning may also be treated using chelation therapy with sodium diethyldithiocarbamate. (L42)
DrugBank ID
HMDB ID HMDB02457
PubChem Compound ID 934
ChEMBL ID
ChemSpider ID 909
KEGG Compound ID C19609
UniProt ID 0
OMIM ID 0
ChEBI ID 49786
BioCyc ID CPD-7425
CTD ID D009532
Stitch ID Nickel
PDB ID NI
ACToR ID 946
Wikipedia Link http://en.wikipedia.org/wiki/Nickel
Creation Date 2009-03-06 18:57:59
Update Date 2014-12-24 20:20:59